Blar i forfatter "Osima, Marit"
-
Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls
Zebaze, Roger; Osima, Marit; Bui, Minh; Lukic, Marko; Wang, Xiaofang; Ghasem-Zadeh, Ali; Eriksen, Erik Fink; Vais, Angela; Shore-Lorenti, Catherine; Ebeling, Peter R.; Seeman, Ego; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-18)Advancing age is accompanied by a reduction in bone formation and remodeling imbalance, which produces microstructural deterioration. This may be partly caused by a diversion of mesenchymal cells towards adipocytes rather than osteoblast lineage cells. We hypothesized that microstructural deterioration would be associated with an increased marrow adiposity, and each of these traits would be independently ... -
Cortical porosity, medullary adiposity, type 2 diabetes mellitus, serum vitamin D, parathyroid hormone, and nonvertebral fractures
Osima, Marit (Doctoral thesis; Doktorgradsavhandling, 2018-03-28)Despite advances in therapies, assessment of fracture risk, and diagnosis of bone fragility, few women and men with high fracture risk receive treatment, even after they develop fracture. To be able to recognize and identify subjects who are at risk for fragility fracture, and to target treatment well, it is important to search for risk factors that are associated with, or ideally, predict fracture. ... -
Ferdigheter i akuttmedisinske situasjoner hos ambulansepersonell og legevaktsleger i UNN helseforetak.
Osima, Marit; Bjerkaas, Ragnhild (Master thesis; Mastergradsoppgave, 2005-09-14) -
Increased cortical porosity and reduced cortical thickness of the proximal femur are associated with nonvertebral fracture independent of Fracture Risk Assessment Tool and Garvan estimates in postmenopausal women
Kral, Rita; Osima, Marit; Borgen, Tove Tveitan; Vestgaard, Roald; Richardsen, Elin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-25)The Fracture Risk Assessment Tool (FRAX) and Garvan Calculator have improved the individual prediction of fracture risk. However, additional bone measurements that might enhance the predictive ability of these tools are the subject of research. There is increasing interest in cortical parameters, especially cortical porosity. Neither FRAX nor Garvan include measurements of cortical architecture, ... -
Serum parathyroid hormone is associated with increased cortical porosity of the inner transitional zone at the proximal femur in postmenopausal women: the Tromsø Study
Osima, Marit; Borgen, Tove Tveitan; Lukic, Marko; Grimnes, Guri; Joakimsen, Ragnar Martin; Eriksen, Erik Fink; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel, 2017-11-14)Summary:<br> Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women. <p> Introduction: <br> Vitamin D deficiency leads to secondary ... -
Women with fracture, unidentified by FRAX, but identified by cortical porosity, have a set of characteristics that contribute to their increased fracture risk beyond high FRAX score and high cortical porosity
Kral, Rita; Osima, Marit; Vestgaard, Roald; Richardsen, Elin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-25)The Fracture Risk Assessment Tool (FRAX) is widely used to identify individuals at increased risk for fracture. However, cortical porosity is associated with risk for fracture independent of FRAX and is reported to improve the net reclassification of fracture cases. We wanted to test the hypothesis that women with fracture who are unidentified by high FRAX score, but identified by high cortical ... -
Women with type 2 diabetes mellitus have lower cortical porosity of the proximal femoral shaft using low-resolution CT than nondiabetic women, and increasing glucose is associated with reduced cortical porosity
Osima, Marit; Kral, Rita; Borgen, Tove Tveitan; Høgestøl, Ingvild Kristine; Joakimsen, Ragnar Martin; Eriksen, Erik Fink; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-01)<p>Increased cortical porosity has been suggested as a possible factor increasing fracture propensity in patients with type 2 diabetes mellitus (T2DM). This is a paradox because cortical porosity is generally associated with high bone turnover, while bone turnover is reduced in patients with T2DM. We therefore wanted to test the hypothesis that women with T2DM have lower bone turnover markers (BTM) ...